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All-in-One Nuclease (Benzonase Nuclease)

Universal nuclease, also known as broad-spectrum nuclease, is a genetically engineered enzyme derived from Serratia marcescens. It degrades all forms of DNA and RNA—including single‑stranded, double‑stranded, linear, circular, native, and denatured nucleic acids—cleaving them into 5′‑monophosphate oligonucleotides of 3–8 nucleotides in length, without exhibiting sequence‑specificity. Moreover, universal nuclease maintains high stability and enzymatic activity across an exceptionally wide range of conditions (e.g., 6 M urea, 0.1 M guanidine HCl, 0.4% Triton X‑100, 0.1% SDS, 1 mM EDTA, 1 mM PMSF), making it an ideal choice for various scientific applications as well as for the vaccine, protein, and polysaccharide pharmaceutical industries, where it effectively removes residual nucleic acids from samples or products, thereby enhancing sample purity and product bioactivity. This product is expressed in E. coli.

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Functional food

Pharmaceutical intermediate

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Product Information
Universal nuclease, also known as broad-spectrum nuclease, is a genetically engineered enzyme derived from Serratia marcescens. It degrades all forms of DNA and RNA—including single‑stranded, double‑stranded, linear, and circular nucleic acids, as well as native and denatured species—cleaving them into 5′‑monophosphate oligonucleotides of 3–8 nucleotides in length, without exhibiting sequence‑specificity. Moreover, universal nuclease maintains high stability and enzymatic activity across an exceptionally wide range of conditions (e.g., 6 M urea, 0.1 M guanidine HCl, 0.4% Triton X‑100, 0.1% SDS, 1 mM EDTA, 1 mM PMSF), making it an ideal choice for various scientific applications and for the vaccine, protein, and polysaccharide pharmaceutical industries. It effectively removes residual nucleic acids from samples or products, thereby enhancing sample purity and improving the biological efficacy of finished formulations. This product is expressed in E. coli.
Product Applications
It is used to remove DNA and RNA from biological products; it helps reduce the viscosity of cell lysates; and in experiments such as two-dimensional electrophoresis, ELISA, chromatographic analysis, and footprinting, treating nucleic acid‑containing protein samples with a universal nuclease can enhance resolution and improve recovery yields.

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Committed to providing high-quality bioactive solutions for human health, animal nutrition, and agricultural biotechnology.

Shaoxing Jawin Biotechnology Co., Ltd.

Phone:0575-82161872

Email:info@jawinbio.com

Address: 3rd Floor, Building 3, No. 36 Kangyang Avenue, Hangzhou Bay Economic and Technological Development Zone, Shangyu District, Shaoxing City, Zhejiang Province

Website Development: China Enterprise Dynamics, Shaoxing

Telephone：0575-82161872

Email box：info@jawinbio.com

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