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2026.09.07

Preparation of spleen aminopeptide-loaded pH- responsive oral hydrogel microspheres for improving recurrent respiratory infection in children

Direct oral intervention of spleen aminopeptide (SA) would be limited because of its varied swelling and release rate in different pH environments of digestive fluids. Herein, pH-responsive hydrogel microspheres (3.67 ± 0.04 mm) with positive SA-loaded chitosan (Cs) core and negative alginate (ALG) shell were prepared. Entrapment efficiency was 76.22% and loading rate of SA was 35.17%. Besides the hydrogen bonding, a strong core/shell structure was constructed by forming imine bond via the Schiff base reaction of amino group inCs with ketone group on SA. In vitro simulated digestion showed that the swelling rate of microspheres was 192.8% (pH 1.2), 2481.5% (pH 6.8), and 1144.3% (pH 7.4). The release rate of SA was 0.9% in simulated gastric fluid for 2 h, 6.0% in simulated intestinal fluid for 2 h and continuous release in simulated colonic fluid for 24 h with a cumulative release rate of 92.4%. After treatment, the observation group exhibited increasing levels of CD3+, CD4+, CD4+/CD8+, IgA, IgG and IgM. Total effective rate in observation group was 96.15%, being higher than that in control group (84.31%). This work provided a valuable reference for preparing drug-loaded hydrogels to improve the recurrent respiratory infection in children.

2026.09.04

Application of Bacillus velezensis JWBIO-01

Strain JWBIO-01 is a probiotic bacterium isolated from the intestinal tract of the speckled bamboo shark, identified as Bacillus velezensis, previously known as Bacillus methylotrophicus and Bacillus amylolyticus. Experimental results demonstrate that the bacterial suspension of JWBIO-01 effectively inhibits the proliferation of both bacteria and fungi. Furthermore, when the spray-dried fermentation powder is added to goat drinking water at a concentration of 400 ppm (2 g per 50 kg of tap water), it not only significantly reduces the incidence of urinary calculi in goats but also enhances their survival rate. Therefore, the spray-dried fermentation powder of this invention holds substantial significance for the prevention of urinary tract stone disease in goats. In the group of Large White pigs fed with probiotics, pathogenic microorganisms—including Fusobacteriota, Propionigenium, Vibrio, and others—were markedly reduced, maintaining harmful microbial populations at very low levels. This lowered the likelihood of illness and improved the fattening performance of the pigs. Probiotics not only enhance poultry production performance and immunity but also help mitigate environmental pollution and curb the overuse of antibiotics. Rabbits fed diets supplemented with probiotics exhibited a significant reduction in disease incidence, a slight increase in feed consumption, and higher meat‑gain rates, thereby delivering greater economic returns to farmers.

2026.09.03

The 2026 Comprehensive Encyclopedia of Single-Domain Antibodies: A Complete Analysis of Their Properties, Preparation, and Application Areas

This article compiles the latest research findings in the field of single-domain antibodies as of 2026, offering a comprehensive scientific overview of key topics such as the definition, structural features, preparation methods, and potential applications of single-domain antibodies. It compares the strengths and limitations of various approaches, addresses common industry questions, and provides biologists and pharmaceutical R&D professionals with a reliable, expert‑level reference on single-domain antibodies.

2026.09.03

The 2026 Comprehensive Encyclopedia of Animal-Derived Bioactive Peptides: A Professional, All‑Encompassing Analysis of Sources, Benefits, and Applications

This article focuses on bioactive peptides of animal origin, drawing on the latest industry research findings through 2026 and the R&D expertise of domestic peptide‑producing companies to create a comprehensive knowledge resource. It systematically examines these peptides from the perspectives of definition and characteristics, sources and classifications, extraction processes, and application areas, addressing common questions from both consumers and industry professionals and offering authoritative guidance.

2026.09.03

The 2026 Comprehensive Encyclopedia of Bacillus velezensis: A Complete Analysis of Its Characteristics, Applications, and Industry Value

This article, drawing on the latest research data from the microbial industry in 2026, systematically compiles core knowledge about Bacillus velezensis. It examines the topic across multiple dimensions—including definition and classification, biological characteristics, application areas, and preservation methods—supplemented by comparative tables of key parameters and a section of frequently asked questions, thereby providing practitioners in the bioagriculture and biopharmaceutical sectors with a reliable, expert‑level reference on Bacillus velezensis.

2026.09.03

2026 Low-Molecular-Weight Heparin Industry Trends: Shaoxing Jiayun Bio Analyzes the Latest Development Dynamics

This paper draws on the latest publicly available data for the low-molecular-weight heparin industry as of 2026, analyzing key developments such as the current market landscape, technological advancements, supply-chain shifts, regulatory updates, and emerging demand trends. It compiles comparative data across different manufacturing processes, addresses frequently asked questions among industry practitioners, and provides valuable insights to support decision-making by relevant enterprises.

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